Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling

Oncotarget. 2011 Nov;2(11):820-1. doi: 10.18632/oncotarget.348.
No abstract available

Publication types

  • Editorial

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / metabolism*
  • Fumarate Hydratase / genetics
  • Fumarate Hydratase / metabolism*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Kelch-Like ECH-Associated Protein 1
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / metabolism*
  • Kidney Neoplasms / pathology
  • Leiomyomatosis / genetics
  • Leiomyomatosis / metabolism*
  • Leiomyomatosis / pathology
  • Neoplastic Syndromes, Hereditary / genetics
  • Neoplastic Syndromes, Hereditary / metabolism*
  • Neoplastic Syndromes, Hereditary / pathology
  • Signal Transduction / physiology*
  • Skin Neoplasms
  • Uterine Neoplasms

Substances

  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Intracellular Signaling Peptides and Proteins
  • KEAP1 protein, human
  • Kelch-Like ECH-Associated Protein 1
  • Fumarate Hydratase

Supplementary concepts

  • Hereditary leiomyomatosis and renal cell cancer