Strontium promotes cell proliferation and suppresses IL-6 expression in human PDL cells

Ann Anat. 2012 Mar 20;194(2):208-11. doi: 10.1016/j.aanat.2011.09.008. Epub 2011 Oct 14.

Abstract

This study was designed to investigate the effect of strontium on human PDL cells in vitro. Strontium is used to treat osteoporosis because of its bone formation promoting effect on osteoblast cells. This investigation presents evidence that strontium promotes PDL cell proliferation. Simultaneously, strontium suppresses the expression of the inflammation-promoting cytokine IL-6. The observed effect of strontium on PDL cells supports its use it in guided dental tissue regeneration.

MeSH terms

  • Adolescent
  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Female
  • Guided Tissue Regeneration, Periodontal
  • Humans
  • Interleukin-6 / antagonists & inhibitors*
  • Interleukin-6 / biosynthesis*
  • Osteoblasts / drug effects
  • Periodontal Ligament / cytology*
  • Periodontal Ligament / drug effects
  • Periodontal Ligament / metabolism*
  • RNA / biosynthesis
  • RNA / genetics
  • Real-Time Polymerase Chain Reaction
  • Strontium / pharmacology*

Substances

  • Interleukin-6
  • RNA
  • Strontium