The new HLA allele, HLA-A*03:57, differs from HLA-A*03:01 by two amino acids at positions 76 and 77 in the α2 domain affecting the pocket F of the peptide-binding groove

Tissue Antigens. 2012 Feb;79(2):131-2. doi: 10.1111/j.1399-0039.2011.01794.x. Epub 2011 Nov 3.

Abstract

HLA-A*03:57 has two amino acid exchanges in exon 2 at adjacent positions of the peptide-binding groove.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Substitution / genetics*
  • Amino Acid Substitution / immunology
  • Amino Acids
  • Exons
  • Germany
  • HLA-A3 Antigen / genetics*
  • HLA-A3 Antigen / immunology
  • HLA-A3 Antigen / metabolism
  • Haplotypes
  • Histocompatibility Testing
  • Humans
  • Peptides / metabolism
  • Polymerase Chain Reaction
  • Protein Binding
  • Protein Structure, Tertiary
  • Sequence Analysis, DNA
  • Stem Cell Transplantation
  • White People

Substances

  • Amino Acids
  • HLA-A*03 antigen
  • HLA-A3 Antigen
  • Peptides