Abstract
A few facile synthetic pathways for bicyclic aminopyridinol antioxidants are presented. Attachment of a long alkyl chain to the bicyclic pyridinol scaffold was established using ester linkage. Non-substituted pyrrolopyridinols and 1,3-oxazine-fused pyridinols were also synthesized as novel antioxidant scaffolds. Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Aminopyridines / chemical synthesis
-
Aminopyridines / chemistry*
-
Antioxidants / chemical synthesis
-
Antioxidants / chemistry*
-
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis
-
Bridged Bicyclo Compounds, Heterocyclic / chemistry*
-
Molecular Structure
-
Pyridoxine / chemistry*
Substances
-
Aminopyridines
-
Antioxidants
-
Bridged Bicyclo Compounds, Heterocyclic
-
Pyridoxine