Functionalized 2,3-dihydrofurans via palladium-catalyzed oxyarylation of α-allyl-β-ketoesters

Org Biomol Chem. 2011 Dec 21;9(24):8233-6. doi: 10.1039/c1ob06593a. Epub 2011 Nov 1.

Abstract

The palladium-catalyzed reaction of (hetero)aryl bromides, chlorides, and nonaflates with α-allyl-β-ketoesters provides ready efficient access to functionalized 2,3-dihydrofurans. The reaction tolerates several useful substituents including chloro, fluoro, ether, ketone, ester, cyano, and nitro groups.

MeSH terms

  • Catalysis
  • Esters / chemistry*
  • Furans / chemical synthesis*
  • Furans / chemistry
  • Ketones / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Esters
  • Furans
  • Ketones
  • 2,3-dihydrofuran
  • Palladium