Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases

Takehiro Takahashi; Yoshihide Asano; Eisuke Amiya; Masaru Hatano; Zenshiro Tamaki; Atsuko Ozeki; Aya Watanabe; Shuichi Kawarasaki; Tomoko Nakao; Takashi Taniguchi; Yohei Ichimura; Tetsuo Toyama; Masafumi Watanabe; Yasunobu Hirata; Ryozo Nagai; Shinichi Sato

doi:10.1007/s10165-011-0545-1

Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases

Mod Rheumatol. 2012 Aug;22(4):598-601. doi: 10.1007/s10165-011-0545-1. Epub 2011 Oct 21.

Authors

Takehiro Takahashi¹, Yoshihide Asano, Eisuke Amiya, Masaru Hatano, Zenshiro Tamaki, Atsuko Ozeki, Aya Watanabe, Shuichi Kawarasaki, Tomoko Nakao, Takashi Taniguchi, Yohei Ichimura, Tetsuo Toyama, Masafumi Watanabe, Yasunobu Hirata, Ryozo Nagai, Shinichi Sato

Affiliation

¹ Department of Dermatology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

PMID: 22015621
DOI: 10.1007/s10165-011-0545-1

Abstract

Intravenous cyclophosphamide pulse therapy (IVCY) exerts its efficacy against interstitial lung disease (ILD) associated with systemic sclerosis (SSc) by restoring vascular injuries as well as aberrant immune activation. We recently experienced two patients with SSc-ILD in whom the values of brachial flow-mediated dilation (FMD) reflected the efficacy of IVCY. We herein report the details of these cases and discuss the potential of FMD to predict and evaluate the effect of IVCY on SSc-ILD.

Publication types

Case Reports

MeSH terms

Aged
Cough / drug therapy*
Cough / physiopathology
Cyclophosphamide / administration & dosage
Cyclophosphamide / therapeutic use*
Dyspnea / drug therapy*
Dyspnea / physiopathology
Endothelium, Vascular / drug effects*
Endothelium, Vascular / physiopathology
Female
Humans
Immunosuppressive Agents / therapeutic use*
Injections, Intravenous
Lung Diseases, Interstitial / complications
Lung Diseases, Interstitial / diagnosis
Lung Diseases, Interstitial / drug therapy*
Middle Aged
Pulse Therapy, Drug
Scleroderma, Systemic / complications
Scleroderma, Systemic / diagnosis
Scleroderma, Systemic / drug therapy*
Skin / blood supply
Skin / pathology
Treatment Outcome
Vasodilation / drug effects

Substances

Immunosuppressive Agents
Cyclophosphamide