No significant association between Catechol-O-methyl transferase (COMT) -287A/G gene polymorphism and Tourette's syndrome in family-based association study in Chinese Han population

Shiguo Liu; Mingji Yi; Fengguang Qi; Yuping Sun; Fengyuan Che; Xu Ma

doi:10.1007/s00787-011-0226-9

No significant association between Catechol-O-methyl transferase (COMT) -287A/G gene polymorphism and Tourette's syndrome in family-based association study in Chinese Han population

Eur Child Adolesc Psychiatry. 2011 Dec;20(11-12):593-6. doi: 10.1007/s00787-011-0226-9. Epub 2011 Oct 19.

Authors

Shiguo Liu¹, Mingji Yi, Fengguang Qi, Yuping Sun, Fengyuan Che, Xu Ma

Affiliation

¹ Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, China.

PMID: 22009217
DOI: 10.1007/s00787-011-0226-9

Abstract

To identify the association of Catechol-O-methyl transferase (COMT) -287A/G polymorphism with susceptibility to TS in Chinese Han population. We evaluated the genetic contribution of the COMT -287A/G polymorphism in 108 TS patients including all their parents in Chinese Han population using transmission disequilibrium test and haplotype relative risk design. Our results revealed that no significant association was found in COMT -287A/G genotypic and allelic frequencies with TS. Our results also suggested that there may be a lack of association between the TS and -287A/G polymorphism of COMT in Chinese Han population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Catechol O-Methyltransferase / blood
Catechol O-Methyltransferase / genetics*
Child
Child, Preschool
China
Family*
Female
Genetic Predisposition to Disease / genetics
Haplotypes
Humans
Male
Observer Variation
Polymorphism, Genetic / genetics*
Polymorphism, Single Nucleotide / genetics
Tourette Syndrome / blood
Tourette Syndrome / genetics*

Substances

Catechol O-Methyltransferase