Abstract
We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardial hypertrophy was estimated by measuring body weight, heart-weight-to-body-weight ratio and ventricular free wall thickness. Moderate myocardial hypertrophy without heart failure was established in fludrocortisone/salt group in 4 weeks. Our method is effective and low cost, and it provides a model of hypertrophic heart.
MeSH terms
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Administration, Oral
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Animals
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / toxicity
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Cardiomegaly / chemically induced*
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Cardiomegaly / diagnosis
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Cardiomegaly / physiopathology
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Fludrocortisone / administration & dosage
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Fludrocortisone / toxicity*
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Heart Ventricles / drug effects*
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Heart Ventricles / physiopathology
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Male
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Rats
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Rats, Wistar
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Sodium Chloride / administration & dosage
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Sodium Chloride / toxicity*
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Ventricular Remodeling / drug effects*
Substances
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Anti-Inflammatory Agents
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Sodium Chloride
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Fludrocortisone