Abstract
Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain, Agrobacterium tumefaciens NTL4.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Agrobacterium tumefaciens / drug effects
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Agrobacterium tumefaciens / physiology
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Furans / chemistry
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Furans / pharmacology*
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Peroxidases / chemistry*
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Peroxidases / isolation & purification
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Peroxidases / physiology
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Quorum Sensing / drug effects*
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Rhodophyta / enzymology*
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beta-Galactosidase / metabolism
Substances
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Furans
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Peroxidases
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bromide peroxidase
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beta-Galactosidase