Naked-eye sensitive detection of nuclease activity using positively-charged gold nanoparticles as colorimetric probes

Chem Commun (Camb). 2011 Dec 7;47(45):12301-3. doi: 10.1039/c1cc15994a. Epub 2011 Oct 17.

Abstract

Positively-charged gold nanoparticles can effectively differentiate long DNA and fragmented DNA, thus providing a simple and visual approach to colorimetric detection of nuclease activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorimetry*
  • DNA / metabolism
  • Deoxyribonucleases / metabolism*
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*

Substances

  • Gold
  • DNA
  • Deoxyribonucleases