Abstract
A new convenient and scalable synthesis of phenylacetic acids has been developed via the iodide catalyzed reduction of mandelic acids. The procedure relies on in situ generation of hydroiodic acid from catalytic sodium iodide, employing phosphorus acid as the stoichiometric reductant.
MeSH terms
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Acids / chemistry
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Catalysis
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Iodides / chemistry*
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Iodine Compounds / chemistry
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Mandelic Acids / chemistry
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Molecular Structure
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Oxidation-Reduction
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Phenylacetates / chemical synthesis*
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Phenylacetates / chemistry
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Stereoisomerism
Substances
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Acids
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Iodides
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Iodine Compounds
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Mandelic Acids
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Phenylacetates
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hydroiodic acid
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phenylacetic acid