(WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation

Alexios-Leandros Skaltsounis; Nicolas Gaboriaud-Kolar

doi:10.1517/13543776.2011.625406

(WO2011057959) indole and indazole derivatives as glycogen synthase activators: a patent evaluation

Expert Opin Ther Pat. 2011 Dec;21(12):1925-9. doi: 10.1517/13543776.2011.625406. Epub 2011 Oct 12.

Authors

Alexios-Leandros Skaltsounis¹, Nicolas Gaboriaud-Kolar

Affiliation

¹ University of Athens, Department of Pharmacy and Natural Products Chemistry, Panepistimiopolis Zografou, GR-15771 Athens, Greece. skaltsounis@pharm.uoa.gr

PMID: 21988345
DOI: 10.1517/13543776.2011.625406

Abstract

Scientific evaluation of a patent aiming for the development of indole and indazole derivatives from biaryloxymethylarene as glycogen synthase activators, a key enzyme involved in type 2 diabetes mellitus.

Publication types

Review

MeSH terms

Animals
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / enzymology
Drug Design
Enzyme Activation
Enzyme Activators / chemistry
Enzyme Activators / pharmacology*
Enzyme Activators / therapeutic use
Glycogen Synthase / metabolism*
Humans
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology*
Hypoglycemic Agents / therapeutic use
Indazoles / chemistry
Indazoles / pharmacology*
Indazoles / therapeutic use
Indoles / chemistry
Indoles / pharmacology*
Indoles / therapeutic use
Molecular Structure
Patents as Topic
Structure-Activity Relationship

Substances

Enzyme Activators
Hypoglycemic Agents
Indazoles
Indoles
Glycogen Synthase