ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression

Bioinformatics. 2011 Dec 1;27(23):3317-8. doi: 10.1093/bioinformatics/btr548. Epub 2011 Oct 3.

Abstract

Summary: We introduce ProfileChaser, a web server that allows for querying the Gene Expression Omnibus based on genome-wide patterns of differential expression. Using a novel, content-based approach, ProfileChaser retrieves expression profiles that match the differentially regulated transcriptional programs in a user-supplied experiment. This analysis identifies statistical links to similar expression experiments from the vast array of publicly available data on diseases, drugs, phenotypes and other experimental conditions.

Availability: http://profilechaser.stanford.edu

Contact: abutte@stanford.edu

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • Cell Line, Tumor
  • Databases, Genetic
  • Female
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors / genetics
  • Gene Expression Profiling*
  • Genome-Wide Association Study
  • Humans
  • Internet*
  • Male
  • Oligonucleotide Array Sequence Analysis*
  • Prostatic Neoplasms / drug therapy
  • Receptors, Estrogen
  • User-Computer Interface

Substances

  • Forkhead Box Protein O3
  • Forkhead Transcription Factors
  • FoxO3 protein, mouse
  • Receptors, Estrogen