Abstract
Epidermolysis bullosa acquisita (EBA) is a rare, acquired, subepidermal blistering disease characterized by autoantibodies directed against type VII collagen, the major component of anchoring fibrils. We report a 5-year-old Chinese boy who presented with extensive lesions consisting of disseminated pruritic vesicles and tense blisters. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The disease was controlled with a combination of prednisone and dapsone.
© 2011 Wiley Periodicals, Inc.
MeSH terms
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Asian People
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Autoantibodies / blood
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Autoantibodies / immunology
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Basement Membrane / immunology
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Child, Preschool
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Collagen Type VII / immunology
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Dapsone / therapeutic use
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Dermatologic Agents / therapeutic use
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Drug Therapy, Combination
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Epidermolysis Bullosa Acquisita / diagnosis*
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Epidermolysis Bullosa Acquisita / drug therapy
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Epidermolysis Bullosa Acquisita / pathology
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Fluorescent Antibody Technique
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Humans
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Immunoblotting
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Male
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Prednisone / therapeutic use
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Treatment Outcome
Substances
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Autoantibodies
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Collagen Type VII
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Dermatologic Agents
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Dapsone
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Prednisone