Genomics reaches the clinic: from basic discoveries to clinical impact

Cell. 2011 Sep 30;147(1):14-6. doi: 10.1016/j.cell.2011.09.012.

Abstract

Today, more than ever, basic science research provides significant opportunities to advance our understanding about the genetic basis of human disease. Close interactions among laboratory, computational, and clinical research communities will be crucial to ensure that genomic discoveries advance medical science and, ultimately, improve human health.

MeSH terms

  • 5'-Nucleotidase / metabolism
  • Calcinosis
  • Disease / genetics*
  • Femoral Artery / pathology
  • GPI-Linked Proteins / metabolism
  • Genome-Wide Association Study
  • Genomics*
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Iliac Artery / pathology
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / therapy
  • Male
  • Mutation
  • Peripheral Arterial Disease / genetics
  • Peripheral Arterial Disease / therapy
  • Pharmacogenetics*
  • Rare Diseases / diagnosis
  • Rare Diseases / genetics
  • X-Linked Inhibitor of Apoptosis Protein / genetics
  • X-Linked Inhibitor of Apoptosis Protein / metabolism

Substances

  • GPI-Linked Proteins
  • X-Linked Inhibitor of Apoptosis Protein
  • XIAP protein, human
  • 5'-Nucleotidase
  • NT5E protein, human