High genetic diversity including potential new subtypes of hepatitis C virus genotype 6 in Lao People's Democratic Republic

Clin Microbiol Infect. 2011 Dec;17(12):E30-4. doi: 10.1111/j.1469-0691.2011.03665.x. Epub 2011 Sep 29.

Abstract

Sera from 105 anti-HCV-positive first-time blood donors collected in 2004, 2005 and 2008 in different provinces in Laos were investigated by PCR. Forty-five samples were positive for HCV (42.86%); two belonged to subtype 1b (2/45, 4.4%) and all others to genotype 6 (43/45, 95.6%), including subtypes 6b, 6h, 6k, 6l, 6n and 6q. Three groups of sequences were not clearly attributable to any genotype 6 subtype, two of which may be regarded as candidates for new subtypes of genotype 6. Two samples were mixed infected with different subtypes or clusters of genotype 6 viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Donors
  • Cluster Analysis
  • Female
  • Genetic Variation*
  • Genotype
  • Hepacivirus / classification*
  • Hepacivirus / genetics*
  • Hepacivirus / isolation & purification
  • Hepatitis C / diagnosis
  • Hepatitis C / immunology
  • Hepatitis C / virology*
  • Hepatitis C Antibodies / blood
  • Humans
  • Laos
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Phylogeny
  • Polymerase Chain Reaction
  • RNA, Viral / genetics
  • Sequence Analysis, DNA
  • Young Adult

Substances

  • Hepatitis C Antibodies
  • RNA, Viral

Associated data

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