Oxidative cyclization of 2-aryl-3-arylamino-2-alkenenitriles to N-arylindole-3-carbonitriles mediated by NXS/Zn(OAc)2

J Org Chem. 2011 Nov 4;76(21):8690-7. doi: 10.1021/jo2012187. Epub 2011 Oct 10.

Abstract

A variety of 2-aryl-3-arylamino-2-alkenenitriles were converted to N-arylindole-3-carbonitriles in a one-pot manner through NBS- or NCS-mediated halogenation followed by Zn(OAc)(2)-catalyzed intramolecular cyclization. It is postulated that the process involves the formation of arylnitrenium ion intermediates, which undergo the electrophilic aromatic substitution to give the cyclized N-arylindole product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Cyclization
  • Indoles / chemistry*
  • Molecular Structure
  • Nitriles / chemistry*
  • Oxidation-Reduction
  • Zinc Compounds / chemistry*

Substances

  • Alkenes
  • Indoles
  • Nitriles
  • Zinc Compounds