Abstract
Serum thymic factor (FTS, zinc-free thymulin) protected mice from death after whole-body X-irradiation. It was significantly radioprotective even when administered after irradiation, but it was more effective when administered both before and after irradiation. The protective effect appears to be due to the enhancement of hematologic recovery in the animals.
MeSH terms
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Animals
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Cell Division / drug effects
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Leukocyte Count / drug effects
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Male
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Mice
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Mice, Inbred C3H
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Organ Size / drug effects
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Radiation Injuries, Experimental / blood
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Radiation Injuries, Experimental / mortality
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Radiation Injuries, Experimental / prevention & control*
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Radiation-Protective Agents*
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Spleen / cytology
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Spleen / drug effects
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Survival Rate
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Thymic Factor, Circulating / administration & dosage
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Thymic Factor, Circulating / pharmacology*
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Thymus Hormones / pharmacology*
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Whole-Body Irradiation*
Substances
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Radiation-Protective Agents
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Thymus Hormones
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Thymic Factor, Circulating