Abstract
Genetic features associated with the bla(NDM-1) gene were investigated in 6 Escherichia coli, 7 Klebsiella pneumoniae, 1 Citrobacter freundii, 1 Proteus mirabilis, and 1 Providencia stuartii isolate of worldwide origin. Clonal diversity was observed for both E. coli and K. pneumoniae. The bla(NDM-1) gene was carried by different plasmid types (IncA/C, IncF, IncL/M, or untypeable) and was likely chromosome borne in two isolates. The bla(NDM-1) plasmids coharbored a variety of resistance determinants, including β-lactamase genes, quinolone resistance genes, and 16S RNA methylase genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Citrobacter freundii / drug effects
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Citrobacter freundii / enzymology
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Citrobacter freundii / genetics
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Drug Resistance, Bacterial / genetics
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology*
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Enterobacteriaceae / genetics*
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Methyltransferases / genetics
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Microbial Sensitivity Tests
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Plasmids / genetics
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Proteus mirabilis / drug effects
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Proteus mirabilis / enzymology
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Proteus mirabilis / genetics
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Methyltransferases
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beta-Lactamases