Treatment of chronic pulmonary blastomycosis with caspofungin

Joëlle Mardini; Bich Nguyen; Marc Ghannoum; Christian Couture; Valéry Lavergne

doi:10.1099/jmm.0.036103-0

Treatment of chronic pulmonary blastomycosis with caspofungin

J Med Microbiol. 2011 Dec;60(Pt 12):1875-1878. doi: 10.1099/jmm.0.036103-0. Epub 2011 Aug 18.

Authors

Joëlle Mardini¹, Bich Nguyen², Marc Ghannoum³, Christian Couture⁴, Valéry Lavergne⁵

Affiliations

¹ University of Montréal, Montréal, Canada.
² Department of Pneumology, Sacré-Coeur Hospital, Montréal, Canada.
³ Department of Medicine, Verdun Hospital, Montréal, Canada.
⁴ Department of Anatomic Pathology and Cytology, Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Canada.
⁵ Department of Medical Microbiology and Infectious Diseases, Sacré-Coeur Hospital, Montréal, Canada.

PMID: 21852530
DOI: 10.1099/jmm.0.036103-0

Abstract

Current practice guidelines recommend that pulmonary blastomycosis be treated with antifungal agents such as amphotericin B and itraconazole. Echinocandins are not recommended because of poor in vitro activity against Blastomyces dermatitidis and lack of supporting clinical data. We report a case of chronic pulmonary blastomycosis treated successfully with caspofungin.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antifungal Agents / therapeutic use*
Blastomyces / drug effects*
Blastomycosis / drug therapy*
Blastomycosis / microbiology
Caspofungin
Echinocandins / therapeutic use*
Humans
Lipopeptides
Lung Diseases, Fungal / drug therapy*
Lung Diseases, Fungal / microbiology
Male

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Caspofungin