Communication: Conformation state diagram of polypeptides: a chain length induced α-β transition

J Chem Phys. 2011 Aug 14;135(6):061101. doi: 10.1063/1.3624928.

Abstract

By using a generic coarse grained polypeptide model, we perform multicanonical molecular dynamics simulations for determining the equilibrium conformation state diagram of a single homopolypeptide chain as a function of the chain length and temperature. The state diagram highlights the thermal regimes of stability for various conformational patterns in polypeptides, including swollen, random and collapsed coils, globular structures, extended and bended α helices, and compact β bundles. Remarkably, at low temperatures we observe a sharp transition from extended α helix to compact β bundles as the chain length increases. This finding indicates that the chain length is one of the intrisic factors that can trigger α-β transformations in a broad class of polypeptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Models, Molecular*
  • Molecular Dynamics Simulation
  • Peptides / chemistry*
  • Phase Transition*
  • Protein Structure, Secondary
  • Temperature

Substances

  • Peptides