Localized fluid collection after carrier-bound fibrin sealant application on liver: complication or proof of efficacy? A long-term clinical observational study

Hepatogastroenterology. 2011 May-Jun;58(107-108):937-42.

Abstract

Background/aims: This study was intended to evaluate the incidence and the long-term outcome of fluid collecting between the hepatic resection surface and a collagen patch. To our knowledge, this is the first study to analyze these aspects.

Methodology: All patients undergoing hepatic resection with patch application from February 2006 to September 2008 were included. At followup, all patients found to have a collection between the liver surface and the patch underwent a CT scan every three months.

Results: Ten patients underwent hepatic resection with the patch application. No mortality occurred and the morbidity rate was 10%. No biliary leaks or free abdominal fluid collection occurred. At follow-up, fluid collections were detected in 60% of cases. The collected fluid did not increase in volume and in 66.6% of the cases the fluid spontaneously reabsorbed after a mean of 5.5 +/- 1.9 months from the operation.

Conclusion: The high incidence, lack of symptoms, favorable evolution and constant stability should be considered a display of patch tightness rather than a complication.

MeSH terms

  • Adult
  • Aged
  • Body Fluids / metabolism*
  • Female
  • Fibrin Tissue Adhesive / administration & dosage*
  • Fibrinogen / administration & dosage
  • Hepatectomy / adverse effects
  • Hepatectomy / methods*
  • Humans
  • Incidence
  • Length of Stay
  • Male
  • Middle Aged
  • Postoperative Complications / epidemiology
  • Postoperative Complications / prevention & control*
  • Prospective Studies
  • Thrombin / administration & dosage
  • Tomography, X-Ray Computed

Substances

  • Fibrin Tissue Adhesive
  • Fibrinogen
  • Thrombin