A prion-like trigger of antiviral signaling

Junqiang Ye; Tom Maniatis

doi:10.1016/j.cell.2011.07.018

A prion-like trigger of antiviral signaling

Cell. 2011 Aug 5;146(3):348-50. doi: 10.1016/j.cell.2011.07.018.

Authors

Junqiang Ye¹, Tom Maniatis

Affiliation

¹ Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antiviral signaling.

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