Emerging toxic neuropathies and myopathies

Neurol Clin. 2011 Aug;29(3):679-87. doi: 10.1016/j.ncl.2011.05.009. Epub 2011 Jul 14.

Abstract

There is a daunting list of toxins that can affect the peripheral nervous system, with new drugs and chemicals added to this list every year. This article focuses on some of the more recent toxic neuropathies and myopathies that have emerged from the medical literature. Among these are toxic myopathies caused by statins, daptomycin, imatinib, hydroxychloroquine, and highly active antiretroviral therapy; neuromuscular junction toxicity caused by tandutinib; toxic peripheral neuropathies caused by bortezomib, angel's trumpet, cisplatin, oxaliplatin, tumor necrosis factor α antagonists, cobalt-chromium, and ixabepilone; and a unique syndrome reported in workers exposed to aerosolized porcine neural tissue.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects
  • Immunosuppressive Agents / adverse effects
  • Muscular Diseases / chemically induced*
  • Neurotoxicity Syndromes / etiology*

Substances

  • Antineoplastic Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Immunosuppressive Agents