Post-traumatic stress disorder (PTSD) is a highly prevalent, often chronic and disabling psychiatric disorder that is associated with significant adverse health and life consequences. Fortunately, there is compelling evidence that cognitive-behavioral therapies, notably exposure therapies, are effective in reducing PTSD symptomology relative to waiting list and active control conditions. Prolonged exposure is a specific exposure therapy program that is considered a first-line evidence-based treatment for PTSD. Unfortunately, barriers to treatment dissemination prevent the majority of individuals with PTSD from receiving evidence-based treatment. Strategies to increase the availability of treatment and boost the efficiency of exposure therapy are now being examined.