Serum levels after everolimus-stent implantation and paclitaxel-balloon angioplasty in an infant with recurrent pulmonary vein obstruction after repaired total anomalous pulmonary venous connection

Pediatr Cardiol. 2011 Oct;32(7):1036-9. doi: 10.1007/s00246-011-0054-1. Epub 2011 Jul 28.

Abstract

Everolimus-eluting stents and paclitaxel-coated balloons are used in the interventional treatment of coronary artery disease in adults to reduce the restenosis rate and in small-vessel disease. Both substances are released into the circulation. We report systemic drug exposure after implantation of one everolimus-eluting stent and dilation with one paclitaxel-coated balloon in an 8-month-old infant, which was used as an innovative therapy for recurrent pulmonary vein stenosis.

Publication types

  • Case Reports

MeSH terms

  • Angiography
  • Angioplasty, Balloon, Coronary / methods*
  • Drug-Eluting Stents*
  • Everolimus
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents / pharmacokinetics
  • Infant, Newborn
  • Male
  • Paclitaxel / pharmacokinetics*
  • Pulmonary Veins / abnormalities*
  • Pulmonary Veins / diagnostic imaging
  • Pulmonary Veins / surgery
  • Pulmonary Veno-Occlusive Disease / blood*
  • Pulmonary Veno-Occlusive Disease / congenital
  • Pulmonary Veno-Occlusive Disease / surgery
  • Recurrence
  • Sirolimus / analogs & derivatives*
  • Sirolimus / pharmacokinetics

Substances

  • Immunosuppressive Agents
  • Everolimus
  • Paclitaxel
  • Sirolimus