Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

Br J Cancer. 2011 Aug 23;105(5):602-5. doi: 10.1038/bjc.2011.271. Epub 2011 Jul 26.

Abstract

Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members.

Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.

Results: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively).

Conclusion: Chlamydia and gonorrhoea may infect the prostate of some infected men.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Chlamydia Infections / blood
  • Chlamydia Infections / epidemiology
  • Gonorrhea / blood
  • Gonorrhea / epidemiology
  • Humans
  • Male
  • Military Personnel / statistics & numerical data
  • Osmolar Concentration
  • Prostate / microbiology
  • Prostate / pathology
  • Prostate / physiology*
  • Prostate-Specific Antigen / analysis
  • Prostate-Specific Antigen / blood*
  • Sexually Transmitted Diseases / blood
  • Sexually Transmitted Diseases / epidemiology
  • Sexually Transmitted Diseases / etiology*
  • Sexually Transmitted Diseases / transmission

Substances

  • Prostate-Specific Antigen