Molecular basis of sulfonamide and trimethoprim resistance in fish-pathogenic Aeromonas isolates

Appl Environ Microbiol. 2011 Oct;77(20):7147-50. doi: 10.1128/AEM.00560-11. Epub 2011 Jul 15.

Abstract

Sulfonamide-trimethoprim-resistant Aeromonas salmonicida and motile Aeromonas spp. from diseased fish of the GERM-Vet study carried the sul1 gene together with mostly cassette-borne trimethoprim resistance genes, including the novel gene dfrA28. The seven dfrA and dfrB genes identified were located mostly in class 1 integrons which commonly harbored other gene cassettes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aeromonas salmonicida / drug effects*
  • Aeromonas salmonicida / genetics
  • Aeromonas salmonicida / isolation & purification
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial*
  • Fish Diseases / microbiology*
  • Fishes
  • Gene Order
  • Genes, Bacterial
  • Gram-Negative Bacterial Infections / microbiology
  • Gram-Negative Bacterial Infections / veterinary*
  • Integrons
  • Sulfonamides / pharmacology*
  • Trimethoprim / pharmacology*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Sulfonamides
  • Trimethoprim