Community transmission in the United States of a CTX-M-15-producing sequence type ST131 Escherichia coli strain resulting in death

J Clin Microbiol. 2011 Sep;49(9):3406-8. doi: 10.1128/JCM.00993-11. Epub 2011 Jul 13.

Abstract

A middle-aged woman developed fatal urosepsis due to a multidrug-resistant Escherichia coli strain representing sequence type ST131, a recently emerged, disseminated, multidrug-resistant extraintestinal pathogen, after presumably having acquired it from her extensively antibiotic-exposed sister with chronic recurrent cystitis. Susceptibility results (reported on day 4) showed resistance to the initially selected regimen.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Cluster Analysis
  • Community-Acquired Infections / diagnosis*
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / transmission
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial
  • Electrophoresis, Gel, Pulsed-Field
  • Escherichia coli / classification
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / isolation & purification*
  • Escherichia coli Infections / diagnosis*
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / transmission
  • Fatal Outcome
  • Female
  • Humans
  • Middle Aged
  • Molecular Typing
  • Sepsis / diagnosis*
  • Sepsis / microbiology
  • Sepsis / transmission
  • United States
  • Urinary Tract Infections / diagnosis*
  • Urinary Tract Infections / microbiology
  • Urinary Tract Infections / transmission
  • beta-Lactamases / metabolism*

Substances

  • DNA, Bacterial
  • beta-lactamase CTX-M-15
  • beta-Lactamases