Abstract
A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Atherosclerosis / diagnostic imaging
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Contrast Media / chemistry*
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Contrast Media / pharmacokinetics
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacokinetics
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Disease Models, Animal
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Gadolinium / chemistry
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Heterocyclic Compounds, 1-Ring / chemistry
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Lipoproteins, LDL / chemistry*
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Lipoproteins, LDL / genetics
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Lipoproteins, LDL / metabolism
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Magnetic Resonance Imaging
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Metal Nanoparticles / chemistry*
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Mice
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Mice, Knockout
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Radionuclide Imaging
Substances
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1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
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Contrast Media
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Coordination Complexes
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Heterocyclic Compounds, 1-Ring
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Lipoproteins, LDL
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Gadolinium