A tertiary amine as a hydride donor: trichlorosilyl triflate-mediated conjugate reduction of unsaturated ketones

Org Lett. 2011 Aug 5;13(15):3968-71. doi: 10.1021/ol2014895. Epub 2011 Jul 7.

Abstract

Bulky tertiary amines, especially dicyclohexylisobutylamine, smoothly reduced α,β-unsaturated ketones in the presence of trichlorosilyl triflate to give the corresponding saturated ketones in excellent yields. Isotope-labeling studies revealed that an α-hydrogen of the amine was transferred to the enones during reduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Ketones / chemistry*
  • Mesylates / chemistry*
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Amines
  • Ketones
  • Mesylates