Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

D H Hsu; R de Waal Malefyt; D F Fiorentino; M N Dang; P Vieira; J de Vries; H Spits; T R Mosmann; K W Moore

doi:10.1126/science.2173142

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1

Science. 1990 Nov 9;250(4982):830-2. doi: 10.1126/science.2173142.

Authors

D H Hsu¹, R de Waal Malefyt, D F Fiorentino, M N Dang, P Vieira, J de Vries, H Spits, T R Mosmann, K W Moore

Affiliation

¹ Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

PMID: 2173142
DOI: 10.1126/science.2173142

Abstract

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.

MeSH terms

Animals
Cell Line
DNA, Viral / genetics
Electrophoresis, Polyacrylamide Gel
Gene Expression Regulation, Viral*
Herpesvirus 4, Human / genetics
Herpesvirus 4, Human / immunology*
Humans
Interleukin-10
Interleukins / biosynthesis*
Killer Cells, Natural / immunology
Mice
Radioimmunoprecipitation Assay
T-Lymphocytes / immunology
Viral Proteins / genetics
Viral Proteins / immunology*

Substances

BCRF1 protein, Human herpesvirus 4
DNA, Viral
Interleukins
Viral Proteins
Interleukin-10