Inhibitory effect of local anesthetics on Na+/H+ antiporter in brush border membrane-reconstituted vesicles

Life Sci. 1990;47(13):1129-33. doi: 10.1016/0024-3205(90)90172-n.

Abstract

The effects of three local anesthetics, lidocaine, dibucaine, and tetracaine, on Na+/H+ antiporter activity were examined in brush border membrane-reconstituted vesicles. Lidocaine at 10 microM inhibited H+ efflux in the presence of an inward Na+ gradient, suggesting that this anesthetic specifically inhibits the Na+/H+ antiporter. On the other hand, dibucaine and tetracaine decreased H+ efflux even in the absence of a Na+ gradient.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthetics, Local / pharmacology*
  • Animals
  • Antiporters
  • Carrier Proteins / drug effects*
  • Dibucaine / pharmacology
  • In Vitro Techniques
  • Kidney / drug effects
  • Kidney / metabolism
  • Lidocaine / pharmacology
  • Microvilli / drug effects*
  • Microvilli / metabolism
  • Protons*
  • Rats
  • Sodium / metabolism*
  • Tetracaine / pharmacology

Substances

  • Anesthetics, Local
  • Antiporters
  • Carrier Proteins
  • Protons
  • Tetracaine
  • Lidocaine
  • Sodium
  • Dibucaine