Organocatalytic asymmetric Strecker reaction of di- and trifluoromethyl ketoimines. Remarkable fluorine effect

Yun-Lin Liu; Tao-Da Shi; Feng Zhou; Xiao-Li Zhao; Xin Wang; Jian Zhou

doi:10.1021/ol201316z

Organocatalytic asymmetric Strecker reaction of di- and trifluoromethyl ketoimines. Remarkable fluorine effect

Org Lett. 2011 Aug 5;13(15):3826-9. doi: 10.1021/ol201316z. Epub 2011 Jun 30.

Authors

Yun-Lin Liu¹, Tao-Da Shi, Feng Zhou, Xiao-Li Zhao, Xin Wang, Jian Zhou

Affiliation

¹ Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, PR China.

PMID: 21718056
DOI: 10.1021/ol201316z

Abstract

A highly enantioselective Strecker reaction of difluoromethyl and trifluoromethyl ketoimines was developed. Remarkable fluorine effect on the reactivity and selectivity is observed and discussed.