Fertility sparing surgery for ovarian tumors in children and young adults

Arch Gynecol Obstet. 2012 Feb;285(2):469-71. doi: 10.1007/s00404-011-1946-2. Epub 2011 Jun 24.

Abstract

Objectives: To study the outcome of fertility conserving surgery for ovarian tumors in children and young adults (≤ 20 years) over 6 years (2003-2009).

Methods: This prospective study included 183 patients diagnosed with ovarian cysts or tumors requiring surgical excision. Ovarian cystectomy/ovariectomy was carried out followed by frozen section histopathology. Malignant cases were subjected to staging laparotomy and fertility sparing surgery.

Results: The median age at diagnosis was 17 years (range 7-20 years). 160/183 (87.4%) were non-neoplastic ovarian cysts or benign tumors. In 131/160 (81.8%) of non-neoplastic and benign tumors, it was possible to preserve the affected ovary. Twenty cases (11%) were diagnosed as primary malignant ovarian tumors, 2/183 (1.1%) were borderline tumors and 1 case (0.55%) was metastatic colonic carcinoma. The median follow up of cases with primary malignant ovarian tumors was 36 months. During this period, two recurrences (9.1%) were detected, both of the germ cell type (immature teratoma and yolk sac tumor). Recurrent cases were managed by local excision and lymph node sampling followed by chemotherapy.

Conclusion: Fertility sparing surgery for malignant ovarian tumors in children and young adults has excellent prognosis and should be attempted whenever possible.

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / therapeutic use
  • Carboplatin / administration & dosage
  • Chemotherapy, Adjuvant
  • Child
  • Cisplatin / therapeutic use
  • Etoposide / therapeutic use
  • Female
  • Fertility Preservation*
  • Humans
  • Neoplasm Recurrence, Local / therapy*
  • Neoplasm Staging
  • Organ Sparing Treatments*
  • Ovarian Cysts / surgery*
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery*
  • Ovariectomy
  • Paclitaxel / administration & dosage
  • Prospective Studies
  • Young Adult

Substances

  • Bleomycin
  • Etoposide
  • Carboplatin
  • Paclitaxel
  • Cisplatin

Supplementary concepts

  • BEP protocol