Lack of association between polymorphism -592A/C in the promoter region of the IL10 gene and Tourette's syndrome in a family-based association study in the Chinese Han population

Shiguo Liu; Mingji Yi; Fengguang Qi; Fengyuan Che; Xu Ma

doi:10.1089/gtmb.2010.0272

Lack of association between polymorphism -592A/C in the promoter region of the IL10 gene and Tourette's syndrome in a family-based association study in the Chinese Han population

Genet Test Mol Biomarkers. 2011 Oct;15(10):733-5. doi: 10.1089/gtmb.2010.0272. Epub 2011 Jun 23.

Authors

Shiguo Liu¹, Mingji Yi, Fengguang Qi, Fengyuan Che, Xu Ma

Affiliation

¹ Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.

PMID: 21699407
DOI: 10.1089/gtmb.2010.0272

Abstract

We evaluated the genetic contribution of the IL10-592A/C polymorphism in 108 trios with Tourette's syndrome (TS) including all their parents in a Chinese Han population by using the transmission disequilibrium test and haplotype relative risk design; no evidence for association or linkage disequilibrium was found between IL10-592A/C polymorphism and TS. These results suggested that IL10 may not play a major role in the development of TS in the Chinese Han population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Asian People / genetics
Case-Control Studies
Child
Child, Preschool
Family
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genetics, Population
Humans
Interleukin-10 / genetics*
Male
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics
Tourette Syndrome / ethnology
Tourette Syndrome / genetics*

Substances

IL10 protein, human
Interleukin-10