Interferon-gamma release assay performance for diagnosing tuberculosis disease in 0- to 5-year-old children

Pediatr Infect Dis J. 2011 Nov;30(11):995-7. doi: 10.1097/INF.0b013e3182272227.

Abstract

QuantiFERON-TB Gold In-Tube performance was evaluated in 19 French immunocompetent children (0.29-5.36 years; median: 1.52) with active tuberculosis. The rate of indeterminates results was 0/19 and the rates of positivity were 6/10 and 9/9 in <2 and 2- to 5-year-old children, respectively. QuantiFERON-TB Gold In-Tube in association with tuberculin skin test could improve diagnosis of tuberculosis even in young children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Female
  • France
  • Humans
  • Immunocompetence
  • Infant
  • Infant, Newborn
  • Interferon-gamma / analysis*
  • Interferon-gamma / immunology
  • Interferon-gamma Release Tests*
  • Mycobacterium tuberculosis / immunology*
  • Mycobacterium tuberculosis / isolation & purification
  • Retrospective Studies
  • Sensitivity and Specificity
  • Tuberculin Test
  • Tuberculosis / blood
  • Tuberculosis / diagnosis*
  • Tuberculosis / immunology

Substances

  • Interferon-gamma