Alternative splicing of mouse brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase mRNA

Biochem Biophys Res Commun. 1990 Aug 16;170(3):1074-81. doi: 10.1016/0006-291x(90)90502-e.

Abstract

A second cDNA for mouse brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase (cDNAII) encoding 420 amino acids was isolated. The only difference from the cDNA obtained previously (cDNAI), which encodes 400 amino acids, was the 5'-end 53 bp. Comparison of the sequence of the mouse gene with the sequence of cDNAII indicates alternative splicing within exon 1. The 5'-end sequence of cDNAII was found in a region of the gene upstream of exon 1 and a second transcription initiation site was identified.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',3'-Cyclic-Nucleotide Phosphodiesterases / genetics*
  • Animals
  • Base Sequence
  • Brain / metabolism*
  • DNA / genetics*
  • Exons
  • Gene Library
  • Mice
  • Molecular Sequence Data
  • RNA Splicing*
  • Sequence Homology, Nucleic Acid

Substances

  • DNA
  • 2',3'-Cyclic-Nucleotide Phosphodiesterases

Associated data

  • GENBANK/M58045
  • GENBANK/M58046
  • GENBANK/M58047