Synthesis of 8-arylquinolines via one-pot Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura coupling

J Org Chem. 2011 Aug 5;76(15):6394-400. doi: 10.1021/jo200904g. Epub 2011 Jul 14.

Abstract

A one-pot process has been developed for the synthesis of 8-arylquinolines via Pd-catalyzed borylation of quinoline-8-yl halides and subsequent Suzuki-Miyaura coupling with aryl halides using n-BuPAd(2) as ligand. Yields of up to 98% were obtained.

MeSH terms

  • Catalysis
  • Hydrocarbons, Halogenated / chemistry*
  • Ligands
  • Molecular Structure
  • Palladium / chemistry*
  • Quinolines / chemical synthesis*
  • Quinolines / chemistry

Substances

  • Hydrocarbons, Halogenated
  • Ligands
  • Quinolines
  • Palladium