Encoded peptide libraries and the discovery of new cell binding ligands

Chem Commun (Camb). 2011 Jul 21;47(27):7638-40. doi: 10.1039/c1cc11668a. Epub 2011 Jun 9.

Abstract

Cells over-expressing integrins or CCR6 were incubated on a DNA microarray, pre-hybridized with a 10,000 member PNA-encoded peptide library allowing novel cell specific ligands for integrins and CCR6 to be identified.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Humans
  • Integrins / metabolism*
  • Ligands
  • Microarray Analysis / methods*
  • Peptide Library*
  • Protein Binding
  • Receptors, CCR6 / metabolism*

Substances

  • Integrins
  • Ligands
  • Peptide Library
  • Receptors, CCR6