A test of the tridimensional personality theory: association with diagnosis and platelet imipramine binding in obsessive-compulsive disorder

Biol Psychiatry. 1990 Jul 1;28(1):41-6. doi: 10.1016/0006-3223(90)90430-a.

Abstract

We administered the Tridimensional Personality Questionnaire (TPQ) to a sample of 25 individuals with obsessive-compulsive disorder (OCD) and 35 normal controls. As predicted, OCD cases scored much higher on the harm avoidance dimension than normal controls. Findings for the novelty seeking and reward dependence dimensions were less dramatic, although compatible with the underlying theory. Despite a theoretical link between the harm avoidance dimension and serotonin-mediated neuropathways, we failed to find an association between this dimension and platelet imipramine binding in either OCD cases or controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arousal / physiology
  • Blood Platelets / metabolism*
  • Carrier Proteins*
  • Dependency, Psychological
  • Humans
  • Imipramine / pharmacokinetics*
  • Motivation
  • Obsessive-Compulsive Disorder / blood
  • Obsessive-Compulsive Disorder / diagnosis*
  • Obsessive-Compulsive Disorder / psychology
  • Personality Tests
  • Psychometrics
  • Receptors, Drug*
  • Receptors, Neurotransmitter / metabolism*

Substances

  • Carrier Proteins
  • Receptors, Drug
  • Receptors, Neurotransmitter
  • imipramine receptor
  • Imipramine