Impact of KRAS and BRAF gene mutations on targeted therapies in colorectal cancer

J Clin Oncol. 2011 Jul 1;29(19):2728-9. doi: 10.1200/JCO.2011.36.1816. Epub 2011 Jun 6.
No abstract available

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Colorectal Neoplasms / drug therapy
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / metabolism*
  • Humans
  • Ligands
  • MAP Kinase Signaling System
  • Models, Biological
  • Mutation*
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins B-raf / biosynthesis*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Proto-Oncogene Proteins p21(ras)
  • Signal Transduction
  • ras Proteins / biosynthesis*
  • ras Proteins / genetics*

Substances

  • Antineoplastic Agents
  • KRAS protein, human
  • Ligands
  • Proto-Oncogene Proteins
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins