Abstract
Markedly inhibitory effects of hybrid liposomes (HL-n) composed of 90 mol% L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(n) dodecyl ethers on the growth of adult T-cell leukemia cells were obtained for the first time. It is noteworthy that HL-n could selectively accumulate into the adult T-cell leukemia cells and induce apoptosis via caspase-3 activation.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis
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Carmustine / administration & dosage
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Cells, Cultured
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Dimyristoylphosphatidylcholine / chemistry
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Drug Delivery Systems*
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Hexoses / chemistry
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Humans
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Inhibitory Concentration 50
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Leukemia-Lymphoma, Adult T-Cell
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Liposomes / administration & dosage*
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Liposomes / chemistry
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Polysorbates / chemistry
Substances
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Hexoses
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Liposomes
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Polysorbates
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sorbitan monolaurate
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Carmustine
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Dimyristoylphosphatidylcholine