Changes in Na+,K(+)-ATPase, Ca2(+)-ATPase and some soluble enzymes related to energy metabolism in brains of patients with Alzheimer's disease

Neurosci Lett. 1990 May 4;112(2-3):338-42. doi: 10.1016/0304-3940(90)90227-z.

Abstract

Hexokinase, lactate dehydrogenase, acylphosphatase, (Na+,K+)-ATPase and Ca2(+)-ATPase of selected areas from postmortem Alzheimer's disease brains were studied. Hexokinase and lactate dehydrogenase were significantly changed in all the examined subcortical nuclei. (Na+,K+)-ATPase activity was altered in several areas of Alzheimer's disease brains. No changes in Ca2(+)-ATPase and acylphosphatase were observed. The main alterations of the assayed enzymes were observed in subcortical areas but not in cortical areas of Alzheimer's disease brains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / metabolism*
  • Calcium-Transporting ATPases / metabolism*
  • Energy Metabolism*
  • Female
  • Hexokinase / metabolism*
  • Humans
  • L-Lactate Dehydrogenase / metabolism*
  • Male
  • Middle Aged
  • Sodium-Potassium-Exchanging ATPase / metabolism*

Substances

  • L-Lactate Dehydrogenase
  • Hexokinase
  • Calcium-Transporting ATPases
  • Sodium-Potassium-Exchanging ATPase