Arylation of α-pivaloxyl ketones with arylboronic reagents via Ni-catalyzed sp3 C-O activation

Chem Commun (Camb). 2011 Jul 7;47(25):7224-6. doi: 10.1039/c1cc11193k. Epub 2011 May 27.

Abstract

A Suzuki-Miyaura coupling of α-pivaloxyl ketones via Ni-catalyzed sp(3) C-O activation to produce α-aryl ketones is developed. This study offers a convenient method to construct α-arylation products from readily available α-hydroxyl carbonyl compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry*
  • Carbon / chemistry*
  • Catalysis
  • Indicators and Reagents / chemistry
  • Ketones / chemistry*
  • Nickel / chemistry*
  • Oxygen / chemistry*

Substances

  • Boron Compounds
  • Indicators and Reagents
  • Ketones
  • Carbon
  • Nickel
  • Oxygen