Background: Despite reform efforts, today's healthcare system faces multiple challenges. Limitations of the current system result in major gaps between evidence and practice, suboptimal quality, inequitable patterns of utilization, inadequate safety and reliability, and unsustainable cost increases. Furthermore, there are major problems of overuse, underuse, and misuse of healthcare. Beyond the healthcare reform legislation passed in 2010 mandate, major transformation of how U.S. A healthcare system is comprised of multiple levels.
Purpose: This article briefly outlines the need for transformational change in healthcare and key conceptual issues.
Methods: We identified literature and concepts relevant to developing a research agenda on transformational change in healthcare. Relevant concepts were further developed through conference presentations and discussions.
Conclusions: This introduction to the 10th Regenstrief Conference proceedings provides a foundation for understanding key terms, questions, and concepts relevant to the area of transformational change in healthcare.