Using the 454 pyrosequencing-based technique in the development of nuclear microsatellite loci in the alpine plant Arabis alpina (Brassicaceae)

Am J Bot. 2011 May;98(5):e103-5. doi: 10.3732/ajb.1000488.

Abstract

Premise of the study: Polymorphic microsatellite markers were developed for the inbred alpine perennial plant Arabis alpine to infer life-history parameters and measure patterns of contemporary gene fl ow within populations.

Methods and results: Using the 454 pyrosequencing technique, 19 microsatellite primer sets were developed for A. alpina . The primer sets were tested on 60 individuals sampled from three sub-populations in the Swiss Alps. The primers amplifi ed di- and trinucleotide repeats with two to fi ve alleles per locus.

Conclusions: Previous attempts to isolate microsatellite loci in A. alpina using enrichment libraries and cross-amplifi cation were diffi cult and produced an insufficient number of polymorphic microsatellite loci. In contrast, next-generation sequencing technology was successful in identifying microsatellite repeats in A. alpina. These newly developed microsatellite primers will be useful to further develop A. alpina into a model species for eco-genomic studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabis / genetics*
  • Cell Nucleus / genetics
  • DNA Primers / genetics*
  • DNA, Plant / genetics*
  • Gene Flow
  • Genetic Markers
  • Inbreeding
  • Microsatellite Repeats*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Switzerland

Substances

  • DNA Primers
  • DNA, Plant
  • Genetic Markers

Associated data

  • GENBANK/HQ599541
  • GENBANK/HQ599542
  • GENBANK/HQ599543
  • GENBANK/HQ599544
  • GENBANK/HQ599545
  • GENBANK/HQ599546
  • GENBANK/HQ599547
  • GENBANK/HQ599548
  • GENBANK/HQ599549
  • GENBANK/HQ599550
  • GENBANK/HQ599551
  • GENBANK/HQ599552
  • GENBANK/HQ599553
  • GENBANK/HQ599554
  • GENBANK/HQ599555
  • GENBANK/HQ599556
  • GENBANK/HQ599557
  • GENBANK/HQ599558
  • GENBANK/HQ599559