C-Abl tyrosine kinase signaling: a new player in AD tau pathology

Curr Alzheimer Res. 2011 Sep;8(6):643-51. doi: 10.2174/156720511796717249.

Abstract

Hyperphosphorylated tau is a cardinal feature of Alzheimer's disease (AD) pathology. The deregulation of kinases that phosphorylate tau can alter normal tau-related processes, including microtubule dynamics, growth cones, and axonal transport, and induce tau aggregation in paired helical filaments. Here we discuss the possible roles of the Abl family of tyrosine kinases, which are essential regulators of cytoskeleton cellular signaling cascades, in AD tau pathology and how the physiological roles of Abl kinases could be connected with the cytoskeletal alterations induced by Aβ aggregates and AD progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Brain / metabolism*
  • Brain / pathology
  • Humans
  • Neurofibrillary Tangles / metabolism*
  • Neurofibrillary Tangles / pathology
  • Proto-Oncogene Proteins c-abl / metabolism*
  • Signal Transduction / physiology*
  • tau Proteins / metabolism*

Substances

  • tau Proteins
  • Proto-Oncogene Proteins c-abl