Biliary excretion of imatinib and its active metabolite CGP74588 during severe hepatic dysfunction

J Clin Pharmacol. 2012 Jul;52(7):1115-20. doi: 10.1177/0091270011409235. Epub 2011 May 20.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / therapeutic use
  • Benzamides
  • Bile / metabolism
  • Gastrointestinal Neoplasms / drug therapy
  • Gastrointestinal Neoplasms / pathology
  • Gastrointestinal Stromal Tumors / drug therapy
  • Gastrointestinal Stromal Tumors / pathology
  • Humans
  • Imatinib Mesylate
  • Liver Diseases / physiopathology*
  • Male
  • Piperazines / pharmacokinetics*
  • Piperazines / therapeutic use
  • Pyrimidines / pharmacokinetics*
  • Pyrimidines / therapeutic use
  • Severity of Illness Index

Substances

  • Antineoplastic Agents
  • Benzamides
  • CGP 74588
  • Piperazines
  • Pyrimidines
  • Imatinib Mesylate