Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds

ChemMedChem. 2011 Aug 1;6(8):1351-6. doi: 10.1002/cmdc.201100098. Epub 2011 May 20.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Binding Sites
  • Catalytic Domain
  • Cathepsin B / antagonists & inhibitors*
  • Cathepsin B / metabolism
  • Cathepsin H / antagonists & inhibitors
  • Cathepsin H / metabolism
  • Cathepsin L / antagonists & inhibitors
  • Cathepsin L / metabolism
  • Cell Line
  • Cell Movement / drug effects
  • Crystallography, X-Ray
  • Humans
  • Microscopy, Fluorescence
  • Nitroquinolines / chemical synthesis
  • Nitroquinolines / chemistry*
  • Nitroquinolines / pharmacology
  • Substrate Specificity

Substances

  • Anti-Bacterial Agents
  • Nitroquinolines
  • nitroxoline
  • Cathepsin B
  • Cathepsin L
  • Cathepsin H